Measles, what you should know.

[BIG_DADDY]

Most of you have heard of the recent measles outbreak mostly linked to Disneyland over the holidays. As of January 27th, a total of 73 cases of measles have been confirmed in the state of California, 48 of which are linked to those who recently visited Disneyland. There are 9 confirmed cases in the Bay Area. Alameda County has 5 cases, 4 of which are probably linked to Disneyland. There are 2 cases each in San Mateo and Santa Clara counties, none of which are directly linked to Disneyland.

Since news of the outbreak, I think it is important to separate fact from the fear that is circulating in the media.

What is measles?

In order to understand what the fear is about, the first thing to understand is what exactly measles is. Measles, also called rubeola, is a highly-contagious viral infection. It is airborne, meaning that it is transmitted by droplets from an infected person’s nose and throat, such as during coughing and sneezing. These droplets can survive in the air and on objects and surfaces for up to 2 hours, but are rapidly killed by heat, light (UV and visible), detergents and organic solvents. Once exposed, the measles virus begins to multiply in the nasal cavity. Two to three days later, the virus continues to replicate and spread from the nasopharynx to the lymphatic system, and eventually to the respiratory tract and other organs. It typically takes 10-12 days for a person to develop symptoms after exposure to measles (the incubation period), but this may be as short as 7 or as long as 18 days.

Takeaway: If the viral replication can be stopped at the time of exposure, this may help prevent actual infection. Consider daily nasal irrigation with Xlear saline nasal spray, neti pot, Neilmed sinus rinse or equivalent. The measles virus is easily inactivated – wash your hands frequently and before you touch your face or eat.

Initial symptoms mimic influenza symptoms, with a fever which can rise as high as 103°F-105°F. This is followed by coryza (runny nose), cough, and conjunctivitis (pinkeye) – the 3 "C’s". With our concurrent flu season in full force, it can be very challenging to differentiate initial measles symptoms with flu symptoms. However, it is during these early stages of measles that we can see what are called "Koplik spots", which are considered definitive for measles. These are discrete white spots on a red base on the inner cheek that appear 1-2 days before, and last 1-2 days after the measles rash develops, and unfortunately are usually gone by the time patients present to a clinic with a rash. The measles rash will develop 2-4 days after upper respiratory symptoms appear and last for approximately 5-6 days. The rash is red and blotchy and some spots may merge, typically starting on the face and moving down the body to the hands and feet, and disappears in that same order. The rash is generally not itchy.

An infected person is contagious for about 4 days before symptoms start, and until 4 days after the rash develops. The secondary "attack rate", or the likelihood of an unprotected person actually getting the infection if they are exposed during this period, is over 90%. The attack rate is highest the younger you are – 94% for children 1 to 4 years of age, and 91% for children 5 to 14 years of age.

The prognosis for measles is generally good. Complications are more likely to occur in children younger than 5 years of age and adults over 20 years of age, and in individuals with vitamin A deficiency, malnutrition, and immunodeficiency. The risk of death is approximately 1-2 per 1,000 cases – with the highest fatality rates seen in children less than 5 years, and in particular those infants aged 4-12 months. Common relatively minor complications include diarrhea in 8%, ear infections in 7% and pneumonia in 6%. While rare, encephalitis (brain infection) can occur in about 1 per 1,000 cases of measles, with an approximately 15% fatality rate, and 25% who will continue to have some residual neurologic damage. While very rare, with anywhere from 1-22 per 100,000 cases, subacute sclerosing panencephalitis (SSPE) is a very serious complication of measles. This is a fatal, progressive degenerative neurologic disease that occurs unpredictably, 7-10 years after a seemingly full recovery from the initial measles infection, resulting eventually in behavioral and cognitive changes, seizures, coma, and death. The risk of SSPE may be higher for patients who contract measles before 2 years of age.

Treatment for measles is supportive. Several studies have shown that high-dose vitamin A may be useful in reducing complications and death from measles, especially in those patients who are deficient in vitamin A. The World Health Organization recommends high-dose vitamin A for all children with acute measles, regardless of vitamin A status. High doses of vitamin A for prolonged periods may have associated toxicity. However, this 2-day protocol is very unlikely to lead to toxicity in the short term. The protocol is as follows – Vitamin A is administered once daily for 2 days at the following doses:
• 50,000 IU for infants aged less than 6 months
• 100,000 IU for infants aged 6–11 months
• 200,000 IU for children aged 12 months and older
Takeaway: Measles is generally a self-limiting disease in most healthy children. Complications are more likely to be severe in individuals who are deficient in vitamin A and malnourished in general. Eat plenty of fruits and vegetables. Avoid sugars and processed foods. Supplement with vitamin D as one of the most important ways to boost your immune system through the winter. Ensure that you and your children get at least the recommended daily allowance of vitamin A. Remember that cod liver oil is a great source of vitamin A AND vitamin D. While optimal daily supplementation levels are not entirely clear, the following are the "tolerable upper intake levels" of vitamin A in international units (IU) as set forth by the Food and Nutrition Board:
Life Stage Upper Limit
Birth to 12 months 2,000 IU
Children 1–3 years 2,000 IU
Children 4–8 years 3,000 IU
Children 9–13 years 5,667 IU
Teens 14–18 years 9,333 IU
Adults 19 years and older 10,000 IU

Antipyretics (fever reducers such as Tylenol and Motrin) have been found in many studies to prolong the course of viral illnesses, like chickenpox and measles. Studies have linked the use of antipyretics for the fever with measles to a significantly higher risk of prolonged illness, complications, and mortality. In fact, one study of children in Ghana during a measles outbreak found higher survival rates in children who had higher fevers and more severe rashes.

Takeaway: Fever is the body’s natural and useful response to infection. Do not succumb to fever phobia. In general, limit antipyretics for when your child is uncomfortable enough that it interferes with staying hydrated or getting adequate sleep. There are many homeopathic medicines that can be used to help the body naturally regulate its fever response. Please consult with your doctor for the most appropriate natural and/or conventional medicines to use should your child develop a fever.

What about the MMR vaccine?

The only vaccination against measles that is currently available is the MMR (measles-mumps-rubella) vaccine, and MMRV (MMR plus chickenpox) vaccine. The measles vaccine is no longer available as a separate single-strain vaccine. The MMR vaccine is a "live-virus" vaccine, which means that you are receiving a live, but weakened version of the viruses to create a mild infection with subsequent antibody response and protection. MMR is typically first given between 12-18 months of age, with a second MMR given between 4-6 years of age. After the first dose, approximately 95% of children vaccinated at 12 months of age, and approximately 98% of children vaccinated at 15 months of age will develop protective measles antibodies. Even one dose can be highly effective in preventing measles. But a second dose (technically not a booster) at 4-6 years of age is recommended to capture the 2-5% of children who did not respond to the first vaccine. This second dose may be administered as soon as 4 weeks after the first dose should there be a question as to efficacy. For children who have had their first MMR but are not yet at the recommended age for their second dose, options include receiving their second MMR before they are 4-6 years of age, or doing bloodwork to check for protective antibody levels (measles titers). Adults do not need a booster if they received a measles vaccine after 1968. For adults who are not sure that they’ve been vaccinated, options include checking measles titers or receiving an MMR vaccine. In outbreaks, the CDC may recommend that children as young as 6 months of age receive the MMR. Children between 6-12 months of age are less likely to respond to the vaccine and make appropriate antibodies, and are still recommended to receive the recommended 2 doses at 12-18 months and 4-6 years. There is evidence that vaccination within 72 hours of exposure to measles may prevent disease in those who are unprotected.

The vaccination status is known for 39 of the California patients who have contracted measles. Of these 39 patients, 32 were unvaccinated and 7 were fully vaccinated.

Takeaway: Even one dose of the MMR appears to be very effective in providing immunity against measles. However, no vaccine is 100% effective. A second dose may be required for some patients, especially those who received their first vaccine at less than 12 months of age. Post-exposure vaccination within 72 hours may be effective. Ensuring adequate nutrition and vitamin A as above continue to be important for all individuals regardless of vaccination status.

Because it is a live-virus vaccine, the MMR is not to be given to pregnant women or to individuals who are immunocompromised or are receiving immunosuppressant therapies. It is also contraindicated in individuals with a history of severe allergic reaction to gelatin, neomycin or any other component of the vaccine. Precautions should be taken in patients with moderate or severe illness with or without fever, or a personal or family history of febrile seizures. The measles virus used in the vaccine is grown in chicken embryo culture, but anaphylactic egg allergy is not considered a contraindication to the vaccine.

Takeaway: There are individuals for whom the MMR vaccine is not an option. Unprotected individuals who cannot receive the MMR vaccine (infants, pregnant women, immunocompromised individuals) may rely on "herd immunity", or high vaccination rates in the community, for their protection.

What are the possible adverse reactions to the MMR? Just as no vaccine is 100% effective, no vaccine is 100% risk-free. The most common adverse reaction is typically due to the replication of the measles vaccine virus to induce a mild illness. This typically occurs 5-12 days after receiving the vaccine, and can include fever for 1-2 days and a rash. Joint pains are seen in 25% of susceptible adult women, due to the rubella component. The risk of febrile seizures increases 3-fold 8-14 days after the MMR vaccine, but is still relatively low. Anaphylaxis and thrombocytopenia (low platelet count) are other rare complications. There may be a link between the measles vaccine and SSPE of about 1 case per million vaccine doses, which is significantly lower than the risk of SSPE from a primary measles infection.

Of biggest concern for many parents is the proposed link between vaccines and autism, and in particular between the MMR vaccine and autism. While the media and common public opinion are quick to say that the link between vaccines and autism has been absolutely disproved, they have not done their due diligence research. The National Vaccine Injury Compensation Program (VICP, also called “vaccine court”), established by Congress in 1986, was created to provide a “no-fault” mechanism to compensate individuals found to be injured by vaccines. By 2010, the VICP had awarded nearly $2 billion to individuals who had suffered vaccine injuries. It has awarded at least 4 families millions of dollars after finding that their children had suffered from brain damage (encephalitis) caused by the MMR and other vaccines, which then resulted in regressive autistic symptoms. Since its inception, the vaccine court has awarded money judgments, often to the tune of millions of taxpayer dollars, to 1,322 families whose children were found to have suffered brain damage from vaccines. In August of 2014, a top research scientist whistleblower at the CDC released information that the CDC had manipulated data in an MMR and autism study to obscure the higher incidence of autism found in African-American boys who received the MMR vaccine before 36 months of age.

That being said, it remains that most children will not develop significant adverse reactions to the MMR vaccine. Is there any way to predict which children may be more vulnerable to vaccine reactions, or any way to prevent these reactions from occurring? In taking a closer look at the cases that were won in vaccine court, one case was won on the grounds that the MMR caused autism by aggravating an underlying mitochondrial disorder, and another case was won on the grounds that the MMR caused autism by triggering an autoimmune reaction called Acute Disseminated Encephalomyelitis (ADEM) which caused irreparable brain inflammation. One might conjecture then, that a child who has a suspected mitochondrial dysfunction, or who has a strong family history of autoimmune illness, may be more at risk for these rare, albeit devastating, reactions. What are possible signs of mitochondrial dysfunction – low muscle tone, easy fatigue/poor endurance, delayed developmental milestones, regressions with illness, and lab evidence (including high serum lactate, high serum CK, high AST, low serum carnitine).

A possible mitochondrial dysfunction and/or family history of autoimmune illness are not absolute contraindications to the MMR vaccine. They are, however, precautions. The risk of adverse vaccine reactions must be weighed against the risk of actual disease. In 2000, measles was thought to be mostly eliminated in the US. Measles is now on the rise, and hopefully will not reach the epidemic proportions it has in Europe. Now that the measles infection rate may potentially be climbing, this risk must be taken into account. Likewise, the community benefit of herd protection for infants and immunocompromised individuals must also be considered. These are all considerations that each parent must take into account for their own children. For children who may have mitochondrial dysfunction, or a family history of autoimmune illness, there are supplements that may help to reduce and prevent potential adverse reactions from the MMR vaccine while still enabling the measles protection that it can afford.

Takeaway: Most children will not experience adverse reactions to the MMR vaccine. Given the increasing prevalence of measles, consideration should be given to getting vaccinated, either now or within 72 hours of known exposure. However, if there is a possibility of mitochondrial dysfunction, or strong family history of autoimmune illness or neurodegenerative disease you may want to reconsider. Supplements to help reduce the risk of adverse reactions. These may include carnitine, coQ10, milk thistle, vitamin A, homeopathic Thuja, and others.



Good information on Hib and MMR.
Most of you have heard of the recent measles outbreak mostly linked to Disneyland over the holidays. As of this writing, a total of 73 cases of measles have been confirmed in the state of California, 48 of which are linked to those who recently visited Disneyland. There are 9 confirmed cases in the Bay Area. Alameda County has 5 cases, 4 of which are probably linked to Disneyland. There are 2 cases each in San Mateo and Santa Clara counties, none of which are directly linked to Disneyland.

Since news of the outbreak, I have received numerous questions about measles and the MMR vaccine. My goal in writing this newsletter now is to hopefully shed some light on this measles epidemic, and to separate fact from the fear that is circulating in the media.

What is measles?

In order to understand what the fear is about, the first thing to understand is what exactly measles is. Measles, also called rubeola, is a highly-contagious viral infection. It is airborne, meaning that it is transmitted by droplets from an infected person’s nose and throat, such as during coughing and sneezing. These droplets can survive in the air and on objects and surfaces for up to 2 hours, but are rapidly killed by heat, light (UV and visible), detergents and organic solvents. Once exposed, the measles virus begins to multiply in the nasal cavity. Two to three days later, the virus continues to replicate and spread from the nasopharynx to the lymphatic system, and eventually to the respiratory tract and other organs. It typically takes 10-12 days for a person to develop symptoms after exposure to measles (the incubation period), but this may be as short as 7 or as long as 18 days.

Takeaway: If the viral replication can be stopped at the time of exposure, this may help prevent actual infection. Consider daily nasal irrigation with Xlear saline nasal spray, neti pot, Neilmed sinus rinse or equivalent. The measles virus is easily inactivated – wash your hands frequently and before you touch your face or eat.

Initial symptoms mimic influenza symptoms, with a fever which can rise as high as 103°F-105°F. This is followed by coryza (runny nose), cough, and conjunctivitis (pinkeye) – the 3 "C’s". With our concurrent flu season in full force, it can be very challenging to differentiate initial measles symptoms with flu symptoms. However, it is during these early stages of measles that we can see what are called "Koplik spots", which are considered definitive for measles. These are discrete white spots on a red base on the inner cheek that appear 1-2 days before, and last 1-2 days after the measles rash develops, and unfortunately are usually gone by the time patients present to a clinic with a rash. The measles rash will develop 2-4 days after upper respiratory symptoms appear and last for approximately 5-6 days. The rash is red and blotchy and some spots may merge, typically starting on the face and moving down the body to the hands and feet, and disappears in that same order. The rash is generally not itchy.

An infected person is contagious for about 4 days before symptoms start, and until 4 days after the rash develops. The secondary "attack rate", or the likelihood of an unprotected person actually getting the infection if they are exposed during this period, is over 90%. The attack rate is highest the younger you are – 94% for children 1 to 4 years of age, and 91% for children 5 to 14 years of age.

The prognosis for measles is generally good. Complications are more likely to occur in children younger than 5 years of age and adults over 20 years of age, and in individuals with vitamin A deficiency, malnutrition, and immunodeficiency. The risk of death is approximately 1-2 per 1,000 cases – with the highest fatality rates seen in children less than 5 years, and in particular those infants aged 4-12 months. Common relatively minor complications include diarrhea in 8%, ear infections in 7% and pneumonia in 6%. While rare, encephalitis (brain infection) can occur in about 1 per 1,000 cases of measles, with an approximately 15% fatality rate, and 25% who will continue to have some residual neurologic damage. While very rare, with anywhere from 1-22 per 100,000 cases, subacute sclerosing panencephalitis (SSPE) is a very serious complication of measles. This is a fatal, progressive degenerative neurologic disease that occurs unpredictably, 7-10 years after a seemingly full recovery from the initial measles infection, resulting eventually in behavioral and cognitive changes, seizures, coma, and death. The risk of SSPE may be higher for patients who contract measles before 2 years of age.

Treatment for measles is supportive. Several studies have shown that high-dose vitamin A may be useful in reducing complications and death from measles, especially in those patients who are deficient in vitamin A. The World Health Organization recommends high-dose vitamin A for all children with acute measles, regardless of vitamin A status. High doses of vitamin A for prolonged periods may have associated toxicity. However, this 2-day protocol is very unlikely to lead to toxicity in the short term. The protocol is as follows – Vitamin A is administered once daily for 2 days at the following doses:
• 50,000 IU for infants aged less than 6 months
• 100,000 IU for infants aged 6–11 months
• 200,000 IU for children aged 12 months and older
Takeaway: Measles is generally a self-limiting disease in most healthy children. Complications are more likely to be severe in individuals who are deficient in vitamin A and malnourished in general. Eat plenty of fruits and vegetables. Avoid sugars and processed foods. Supplement with vitamin D as one of the most important ways to boost your immune system through the winter. Ensure that you and your children get at least the recommended daily allowance of vitamin A. Remember that cod liver oil is a great source of vitamin A AND vitamin D. While optimal daily supplementation levels are not entirely clear, the following are the "tolerable upper intake levels" of vitamin A in international units (IU) as set forth by the Food and Nutrition Board:
Life Stage Upper Limit
Birth to 12 months 2,000 IU
Children 1–3 years 2,000 IU
Children 4–8 years 3,000 IU
Children 9–13 years 5,667 IU
Teens 14–18 years 9,333 IU
Adults 19 years and older 10,000 IU

Antipyretics (fever reducers such as Tylenol and Motrin) have been found in many studies to prolong the course of viral illnesses, like chickenpox and measles. Studies have linked the use of antipyretics for the fever with measles to a significantly higher risk of prolonged illness, complications, and mortality. In fact, one study of children in Ghana during a measles outbreak found higher survival rates in children who had higher fevers and more severe rashes.

Takeaway: Fever is the body’s natural and useful response to infection. Do not succumb to fever phobia. In general, limit antipyretics for when your child is uncomfortable enough that it interferes with staying hydrated or getting adequate sleep. There are many homeopathic medicines that can be used to help the body naturally regulate its fever response. Please consult with your doctor for the most appropriate natural and/or conventional medicines to use should your child develop a fever.

What about the MMR vaccine?

The only vaccination against measles that is currently available is the MMR (measles-mumps-rubella) vaccine, and MMRV (MMR plus chickenpox) vaccine. The measles vaccine is no longer available as a separate single-strain vaccine. The MMR vaccine is a "live-virus" vaccine, which means that you are receiving a live, but weakened version of the viruses to create a mild infection with subsequent antibody response and protection. MMR is typically first given between 12-18 months of age, with a second MMR given between 4-6 years of age. After the first dose, approximately 95% of children vaccinated at 12 months of age, and approximately 98% of children vaccinated at 15 months of age will develop protective measles antibodies. Even one dose can be highly effective in preventing measles. But a second dose (technically not a booster) at 4-6 years of age is recommended to capture the 2-5% of children who did not respond to the first vaccine. This second dose may be administered as soon as 4 weeks after the first dose should there be a question as to efficacy. For children who have had their first MMR but are not yet at the recommended age for their second dose, options include receiving their second MMR before they are 4-6 years of age, or doing bloodwork to check for protective antibody levels (measles titers). Adults do not need a booster if they received a measles vaccine after 1968. For adults who are not sure that they’ve been vaccinated, options include checking measles titers or receiving an MMR vaccine. In outbreaks, the CDC may recommend that children as young as 6 months of age receive the MMR. Children between 6-12 months of age are less likely to respond to the vaccine and make appropriate antibodies, and are still recommended to receive the recommended 2 doses at 12-18 months and 4-6 years. There is evidence that vaccination within 72 hours of exposure to measles may prevent disease in those who are unprotected.

The vaccination status is known for 39 of the California patients who have contracted measles. Of these 39 patients, 32 were unvaccinated and 7 were fully vaccinated.

Takeaway: Even one dose of the MMR appears to be very effective in providing immunity against measles. However, no vaccine is 100% effective. A second dose may be required for some patients, especially those who received their first vaccine at less than 12 months of age. Post-exposure vaccination within 72 hours may be effective. Ensuring adequate nutrition and vitamin A as above continue to be important for all individuals regardless of vaccination status.

Because it is a live-virus vaccine, the MMR is not to be given to pregnant women or to individuals who are immunocompromised or are receiving immunosuppressant therapies. It is also contraindicated in individuals with a history of severe allergic reaction to gelatin, neomycin or any other component of the vaccine. Precautions should be taken in patients with moderate or severe illness with or without fever, or a personal or family history of febrile seizures. The measles virus used in the vaccine is grown in chicken embryo culture, but anaphylactic egg allergy is not considered a contraindication to the vaccine.

Takeaway: There are individuals for whom the MMR vaccine is not an option. Unprotected individuals who cannot receive the MMR vaccine (infants, pregnant women, immunocompromised individuals) may rely on "herd immunity", or high vaccination rates in the community, for their protection.

What are the possible adverse reactions to the MMR? Just as no vaccine is 100% effective, no vaccine is 100% risk-free. The most common adverse reaction is typically due to the replication of the measles vaccine virus to induce a mild illness. This typically occurs 5-12 days after receiving the vaccine, and can include fever for 1-2 days and a rash. Joint pains are seen in 25% of susceptible adult women, due to the rubella component. The risk of febrile seizures increases 3-fold 8-14 days after the MMR vaccine, but is still relatively low. Anaphylaxis and thrombocytopenia (low platelet count) are other rare complications. There may be a link between the measles vaccine and SSPE of about 1 case per million vaccine doses, which is significantly lower than the risk of SSPE from a primary measles infection.

Of biggest concern for many parents is the proposed link between vaccines and autism, and in particular between the MMR vaccine and autism. While the media and common public opinion are quick to say that the link between vaccines and autism has been absolutely disproved, they have not done their due diligence research. The National Vaccine Injury Compensation Program (VICP, also called “vaccine court”), established by Congress in 1986, was created to provide a “no-fault” mechanism to compensate individuals found to be injured by vaccines. By 2010, the VICP had awarded nearly $2 billion to individuals who had suffered vaccine injuries. It has awarded at least 4 families millions of dollars after finding that their children had suffered from brain damage (encephalitis) caused by the MMR and other vaccines, which then resulted in regressive autistic symptoms. Since its inception, the vaccine court has awarded money judgments, often to the tune of millions of taxpayer dollars, to 1,322 families whose children were found to have suffered brain damage from vaccines. In August of 2014, a top research scientist whistleblower at the CDC released information that the CDC had manipulated data in an MMR and autism study to obscure the higher incidence of autism found in African-American boys who received the MMR vaccine before 36 months of age.

That being said, it remains that most children will not develop significant adverse reactions to the MMR vaccine. Is there any way to predict which children may be more vulnerable to vaccine reactions, or any way to prevent these reactions from occurring? In taking a closer look at the cases that were won in vaccine court, one case was won on the grounds that the MMR caused autism by aggravating an underlying mitochondrial disorder, and another case was won on the grounds that the MMR caused autism by triggering an autoimmune reaction called Acute Disseminated Encephalomyelitis (ADEM) which caused irreparable brain inflammation. One might conjecture then, that a child who has a suspected mitochondrial dysfunction, or who has a strong family history of autoimmune illness, may be more at risk for these rare, albeit devastating, reactions. What are possible signs of mitochondrial dysfunction – low muscle tone, easy fatigue/poor endurance, delayed developmental milestones, regressions with illness, and lab evidence (including high serum lactate, high serum CK, high AST, low serum carnitine).

A possible mitochondrial dysfunction and/or family history of autoimmune illness are not absolute contraindications to the MMR vaccine. They are, however, precautions. The risk of adverse vaccine reactions must be weighed against the risk of actual disease. In 2000, measles was thought to be mostly eliminated in the US. Measles is now on the rise, and hopefully will not reach the epidemic proportions it has in Europe. Now that the measles infection rate may potentially be climbing, this risk must be taken into account. Likewise, the community benefit of herd protection for infants and immunocompromised individuals must also be considered. These are all considerations that each parent must take into account for their own children. For children who may have mitochondrial dysfunction, or a family history of autoimmune illness, there are supplements that may help to reduce and prevent potential adverse reactions from the MMR vaccine while still enabling the measles protection that it can afford.

Takeaway: Most children will not experience adverse reactions to the MMR vaccine. Given the increasing prevalence of measles, consideration should be given to getting vaccinated, either now or within 72 hours of known exposure. However, if there is a possibility of mitochondrial dysfunction, or strong family history of autoimmune illness or neurodegenerative disease, Dr. Song and Dr. Ruiz are available to consult with you on supplements to help reduce the risk of adverse reactions. These may include carnitine, coQ10, milk thistle, vitamin A, homeopathic Thuja, and others.

[Lex Luthor]

Originally Posted by Pitt Gorilla

What's the source on that "article"?

I was able to find the source of Big_Daddy's ridiculous article. The claims in the article came from the Weston A. Price foundation, which is led by a couple of people who are neither scientists nor physicians. They specialize in recommending Vegan diets and they tell people that they should drink un-Pasteurized milk. They have a pretty bad reputation for quackery.

The actual article can be found here.

A little info about the foundation can be found here.

[|Zach|]

Originally Posted by Brainiac

I was able to find the source of Big_Daddy's ridiculous article. The claims in the article came from the Weston A. Price foundation, which is led by a couple of people who are neither scientists nor physicians. They specialize in recommending Vegan diets and they tell people that they should drink un-Pasteurized milk. They have a pretty bad reputation for quackery.

The actual article can be found here.

A little info about the foundation can be found here.

Hey great work Big Daddy!

You are who we thought you were.

[Silock]

The problem is that EVEN IF vaccinated individuals can spread the disease, that DOES NOT INVALIDATE the rationale behind vaccinating everyone.

[Dave Lane]

There were like 3-4 days I actually believed this, in 1997

[BigRedChief]

Originally Posted by Silock

The problem is that EVEN IF vaccinated individuals can spread the disease, that DOES NOT INVALIDATE the rationale behind vaccinating everyone.

Every single one of the current 114 documented cases of measles in the USA can be traced back to an unvaccinated person.

[BigRedChief]

Originally Posted by Brainiac

I was able to find the source of Big_Daddy's ridiculous article. The claims in the article came from the Weston A. Price foundation, which is led by a couple of people who are neither scientists nor physicians. They specialize in recommending Vegan diets and they tell people that they should drink un-Pasteurized milk. They have a pretty bad reputation for quackery.

The actual article can be found here.

A little info about the foundation can be found here.

WTF Big Daddy? Thats the lamest scientific source ever.

[|Zach|]

The research linking autism to vaccines is even more bogus than you think

http://www.vox.com/2015/2/2/7965885/...-terrible-than

In 1998, an esteemed medical journal published a paper with a startling conclusion: that the measles, mumps, and rubella vaccine — administered to millions of children across the globe each year — could cause autism.

This study, led by the discredited physician-researcher Andrew Wakefield, is where the current vaccine-autism debate started. It has since been thoroughly eviscerated: The Lancet retracted the paper, investigators have described the research as an "elaborate fraud," and Wakefield has lost his medical license.


But public-health experts say that Wakefield's false data and erroneous conclusions, while resoundingly rejected in the academic world, still drive some parents' current worries about the MMR shot.

Here are five reasons — and many links to further reading — that should remind you just how terrible his research was.

1) Forget the fraud and data manipulation: the MMR vaccine-autism study was bad science

To begin with, Wakefield's association between the MMR vaccine and autism was based on a case report involving only 12 children. "Case reports" are detailed stories about particular patients' medical histories. And — because they basically just stories — they are considered among weakest kinds of medical studies.

In this case, many children have autism and nearly all take the MMR vaccine. Finding, among a group of a dozen children, that most of them happen to have both is not at all surprising and in no way proves that the MMR vaccine causes autism. (Wakefield also proposed a link between the vaccine and a new inflammatory bowel syndrome, which has since been called "autistic enterocolitis" and also discredited.)

But don't stop with the retracted study. The totality of the evidence opposes this vaccine-autism theory. Large-scale studies involving thousands of participants in several countries have failed to establish a link between the MMR vaccine and the mental developmental disorder. As one of the most thorough studies to date showed, nearly half a million kids who got the vaccine were compared to some 100,000 who didn't, and there were no differences in the autism rates between the two groups. "This study provides strong evidence against the hypothesis that MMR vaccination causes autism," the authors wrote in The New England Journal of Medicine.

Studies published in The Lancet, The Journal of Pediatric Infectious Diseases, PLoS One, and — among others — The Journal of Autism and Developmental Disorders have also found no association between the vaccine and autism.

2) Study author Andrew Wakefield manipulated and misrepresented his data


A British investigative journalist, Brian Deer, followed up with the families of each of the 12 kids in the study. He concluded, "No case was free of misreporting or alteration." In other words, Andrew Wakefield, lead author of the original report, manipulated his data. (See the popup chart in this report for details.)

In The British Medical Journal, Deer spells out exactly what he found, and it's rather shocking that this study was ever published in the first place. You learn that the parents of many of the kids deny the conclusions in the study; some of the kids who Wakefield suggested were diagnosed with autism actually weren't; others who Wakefield suggested were "previously normal" actually had pre-existing developmental issues before getting their shots.

3) The paper is based on blood samples Wakefield drew at his kid's birthday party

Even more absurdly, when the General Medical Council (the UK's medical regulator) began to investigate Wakefield, they found that he had paid children at his son's 10th birthday party to donate their blood for his research. That isn't exactly a controlled and ethical setting.

In fact, in deciding to take his UK medical license away, the GMC said Wakefield acted with "callous disregard for the distress and pain the children might suffer."

4) Wakefield filed a patent for an MMR vaccine alternative

Wakefield also had financial conflicts of interest. Among them, while he was discrediting the combination measles-mumps-rubella vaccine, and suggesting parents should give their children single shots over a longer period of time, he was conveniently filing patents for single-disease vaccines.

"For the vast majority of children, the MMR vaccine is fine," he said, "but I believe there are sufficient anxieties for a case to be made to administer the three vaccinations separately." He also suggested the long-term safety studies of the MMR shouldn't be trusted.

Brian Deer's investigation revealed that, in June 1997, he had filed a patent for a supposedly "safer" single measles vaccine. Deer writes, "Although Wakefield denied any such plans, his proposed shot, and a network of companies intended to raise venture capital for purported inventions — including 'a replacement for attenuated viral vaccines', commercial testing kits and what he claimed to be a possible 'complete cure' for autism — were set out in confidential documents."

5) Wakefield has refused to replicate the paper's findings

At the very bedrock of science is the concept of falsification: a scientist runs a test, gathers his findings, and tries to disprove himself by replicating his experiment in other contexts. When that's done, only then can he know that his findings were true.

Wakefield has never done this. As the editor of The BMJ points out, "Wakefield has been given ample opportunity either to replicate the paper's findings, or to say he was mistaken. He has declined to do either." In 2004, 10 of his coauthors on the original paper retracted it, but Wakefield didn't join them, and he has since continued to push his views, including doing the rounds on the anti-vaxxer speakers' circuit and publishing books.

On his own website, he portrays himself as an embattled hero: "In the pursuit of possible links between childhood vaccines, intestinal inflammation, and neurologic injury in children, Dr. Wakefield lost his job in the Department of Medicine at London’s Royal Free Hospital, his country, his career, and his medical license." He even tried to sue the BMJ and Deer, suggesting they were going after him in some sort of vendetta. So far, these lawsuits have gone nowhere.

[jspchief]

Wakefield has been thoroughly exposed as a fraud to the point of losing his medical license, but dumbshits like big daddy and Jenny Mccarthy treat his study as gospel.

[DaFace]

From the 1940s:

[KC native]

@ Big Contagion's hootie style double down.

[Rausch]

I could see there being more reason for worry when things like mercury were still being injected. Hell, just like antibiotics, there's a downside to too much of any medicine.

I wouldn't be putting my kid through 20 vaccinations in fear of every cold or flu.

I also wouldn't take the risk of not protecting them from things like small pox...

[Fish]

We can look at the experiences of several developed countries after they let their immunization levels drop. Three countries – Great Britain, Sweden, and Japan – cut back the use of pertussis vaccine because of fear about the vaccine. The effect was dramatic and immediate. In Great Britain, a drop in pertussis vaccination in 1974 was followed by an epidemic of more than 100,000 cases of pertussis and 36 deaths by 1978. In Japan, around the same time, a drop in vaccination rates from 70% to 20%-40% led to a jump in pertussis from 393 cases and no deaths in 1974 to 13,000 cases and 41 deaths in 1979. In Sweden, the annual incidence rate of pertussis per 100,000 children 0-6 years of age increased from 700 cases in 1981 to 3,200 in 1985. It seems clear from these experiences that not only would diseases not be disappearing without vaccines, but if we were to stop vaccinating, they would come back.

http://scienceblogs.com/insolence/20...-of-the-vacci/

[wazu]

Originally Posted by Gonzo

As many of you know, my son is autistic. He's on the extreme high end... Very sweet, smart and shows very few symptoms of the disorder.
It took several professionals a very long time to diagnose him because of the that very reason. However, he's six and still has a lot of issues with communication. He's got great eye contact, he shows no social dysfunction and loves people. This being said, when he was 18 months old I took him in for his immunizations.
I noticed a sudden personality change less that 2 days later. He seemed to concentrate on things that he previously found trivial. He became very self-sustaining. In other words, I can't come right out and say it was due to the vaccines but if I had to do it over again, I would've had them do one or two at a time spanning a month or two instead of the large amount they gave him all at once.
Would it had made a difference? Who knows. All I know is that he was a different baby after that.

If any of you are having kids, I reccommend asking about this.

Here's a question. How many documented cases of this disorder were there before we started giving so many vaccines? How many do we have now?

I have a friend who experienced exact same thing with his daughter. This was in 2003, and neither he nor I had heard of this connection when he found out she was autistic. He described that his daughter got the shot, and didn't feel good for a couple of days so they thought she was just acting different due to an illness. But she never snapped out of it. Before that she had been waving and saying "Bye Daddy" and "Hi Daddy" and such, but after the shot she went silent.

I had a newborn and his story shook me up so I started googling and of course found all these sites of people making the connection and telling their own similar stories. The belief at the time was that it was thimerosal additive they used in the MMR shot. There was no scientific study that was proving anything, but my friend's story combined with internet speculation freaked me out.

We ended up having our kids take all of the vaccinations except MMR, then when it was time for pre-school they went ahead and got the MMR. We just wanted to give them a few more years of development.

[Fat Elvis]

[BigRedChief]

Originally Posted by wazu

The belief at the time was that it was thimerosal additive they used in the MMR shot. There was no scientific study that was proving anything, but my friend's story combined with internet speculation freaked me out.

Absolutely no evidence, ever, not even a hint of scientific evidence that the MMR caused autism.

Some of you may know Roald Dahl. He's the children's book author that wrote Charlie and the Chocolate Factory, Matilda etc. His daughter died from measles in 1962. Here's what he wrote to help publicize the need for parents to vaccinate their kids.

Here, in part, is what he wrote:

Olivia, my eldest daughter, caught measles when she was seven years old. As the illness took its usual course I can remember reading to her often in bed and not feeling particularly alarmed about it. Then one morning, when she was well on the road to recovery, I was sitting on her bed showing her how to fashion little animals out of coloured pipe-cleaners, and when it came to her turn to make one herself, I noticed that her fingers and her mind were not working together and she couldn’t do anything.
“Are you feeling all right?” I asked her.
“I feel all sleepy,” she said.
In an hour, she was unconscious. In twelve hours she was dead.
The measles had turned into a terrible thing called measles encephalitis and there was nothing the doctors could do to save her. That was twenty-four years ago in 1962, but even now, if a child with measles happens to develop the same deadly reaction from measles as Olivia did, there would still be nothing the doctors could do to help her.
On the other hand, there is today something that parents can do to make sure that this sort of tragedy does not happen to a child of theirs. They can insist that their child is immunised against measles. I was unable to do that for Olivia in 1962 because in those days a reliable measles vaccine had not been discovered. Today a good and safe vaccine is available to every family and all you have to do is to ask your doctor to administer it.”

The article is here:
http://www.washingtonpost.com/news/m...reading-today/