Music RIP Prince - Page 25

siberian khatru · 11:18 AM

http://www.tmz.com/2016/04/21/prince-dead-at-57/

Updated link: http://www.news-journalonline.com/ar...nce-dead-at-57

listopencil · 06-04-2016, 04:37 PM

Quote:

Originally Posted by JASONSAUTO

For sure. I'm sure I've experienced REAL pain in my life, marijuana definitely helps.

I haven't used it myself. But I have very personal first hand experience with people who have, and it helped them quite a bit.

'Hamas' Jenkins · 06-04-2016, 05:09 PM

Quote:

Originally Posted by theelusiveeightrop

Missouri has no such system

If only I had posted that somewhere in the thread.

**SAUTO** · 06-04-2016, 05:09 PM

Quote:

Originally Posted by 'Hamas' Jenkins

If only I had posted that somewhere in the thread.

Lol you were the first to say it

'Hamas' Jenkins · 06-04-2016, 05:10 PM

Quote:

Originally Posted by DaFace

Right, but I can buy that opioids are BETTER purely for the level of pain relief. It's all the other side effects that make them less beneficial.

(I admittedly haven't ever had a significant pain issue nor used opioids though.)

Opioids absolutely are. The error is in stating that cannabinoids have no efficacy as analgesics. They do via multiple pathways that I listed.

'Hamas' Jenkins · 06-04-2016, 05:21 PM

Quote:

Originally Posted by patteeu

Get bent, blowhard. I think you're projecting your own ignorance here. I hadn't taken you for a NORML-style miracle weed nut, but maybe you are. You certainly aren't going to show me any scientific studies demonstrating equivalent effectiveness so take your "scientific knowledge" handwaving somewhere else.

The fact that you are trying to equate me with someone who is lionizing marijuana shows how desperate and ignorant you are.

Regarding the rest of your braindead tripe, here are the scientific studies you asked for, but won't read and won't apologize for bullshitting about:

Mechanism of ActionDronabinol (synthetic delta-9-tetrahydrocannabinol [delta-9-THC]), an active cannabinoid and natural occurring component of Cannabis sativa L. (marijuana), activates cannabinoid receptors CB1 and CB2. Activation of the CB1 receptor produces marijuana-like effects on psyche and circulation, whereas activation of the CB2 receptor does not. Dronabinol has approximately equal affinity for the CB1 and CB2 receptors; however, efficacy is less at CB2 receptors. Activation of the cannabinoid system with dronabinol causes psychological effects that can be divided into 4 groups: affective (euphoria and easy laughter); sensory (increased perception of external stimuli and of the person’s own body); somatic (feeling of the body floating or sinking in the bed); and cognitive (distortion of time perception, memory lapses, difficulty in concentration). Most effects (eg, analgesia, appetite enhancement, muscle relaxation, hormonal actions) are mediated by central cannabinoid receptors (CB1), their distribution reflecting many of the medicinal benefits and adverse effects (Grotenhermen 2003).

Studies demonstrating their efficacy in treating various types of pain:

Neuropathy:

http://www.ncbi.

.nih.gov/pmc/articles/PMC2755639/

Cannabinoids as an adjunct to Opioids for those with long-term/chronic pain:

http://www.ncbi.

.nih.gov/pmc/articles/PMC3728280/

Cannabinoids' multiple uses in treating cancer (extensive references to pain relief).

http://www.ncbi.

.nih.gov/pmc/articles/PMC4171598/

So, yeah. I'm projecting *my* ignorance. If you'd like, I could also shove a database of Clinical Pharmacology up your bloviating cloaca, you degenerate ****ing ****.

Hoopsdoc · 06-04-2016, 06:27 PM

Quote:

Originally Posted by 'Hamas' Jenkins

The fact that you are trying to equate me with someone who is lionizing marijuana shows how desperate and ignorant you are.

Regarding the rest of your braindead tripe, here are the scientific studies you asked for, but won't read and won't apologize for bullshitting about:

Mechanism of ActionDronabinol (synthetic delta-9-tetrahydrocannabinol [delta-9-THC]), an active cannabinoid and natural occurring component of Cannabis sativa L. (marijuana), activates cannabinoid receptors CB1 and CB2. Activation of the CB1 receptor produces marijuana-like effects on psyche and circulation, whereas activation of the CB2 receptor does not. Dronabinol has approximately equal affinity for the CB1 and CB2 receptors; however, efficacy is less at CB2 receptors. Activation of the cannabinoid system with dronabinol causes psychological effects that can be divided into 4 groups: affective (euphoria and easy laughter); sensory (increased perception of external stimuli and of the person’s own body); somatic (feeling of the body floating or sinking in the bed); and cognitive (distortion of time perception, memory lapses, difficulty in concentration). Most effects (eg, analgesia, appetite enhancement, muscle relaxation, hormonal actions) are mediated by central cannabinoid receptors (CB1), their distribution reflecting many of the medicinal benefits and adverse effects (Grotenhermen 2003).

Studies demonstrating their efficacy in treating various types of pain:

Neuropathy:

http://www.ncbi.

.nih.gov/pmc/articles/PMC2755639/

Cannabinoids as an adjunct to Opioids for those with long-term/chronic pain:

http://www.ncbi.

.nih.gov/pmc/articles/PMC3728280/

Cannabinoids' multiple uses in treating cancer (extensive references to pain relief).

http://www.ncbi.

.nih.gov/pmc/articles/PMC4171598/

So, yeah. I'm projecting *my* ignorance. If you'd like, I could also shove a database of Clinical Pharmacology up your bloviating cloaca, you degenerate ****ing ****.

You also guaranteed that Trump had no interest in the presidency and would drop out before the primaries, iirc, so it's not like you've NEVER been wrong about something.

Just saying.

**Mr. Flopnuts** · 06-04-2016, 06:31 PM

Quote:

Originally Posted by raybec 4

It goes for a buck a milligram

In big cities. It's 50 cents a MG in rural areas where demand is lower.

**Mr. Flopnuts** · 06-04-2016, 06:33 PM

Quote:

Originally Posted by cdcox

You are blessedly clueless about addiction. I hope you are fortunate enough to stay that way.

"Addicts make choices!!!"

Addicts make choices that always lead to unintended consequences...

**Mr. Flopnuts** · 06-04-2016, 06:35 PM

Quote:

Originally Posted by theelusiveeightrop

Let m see if I have this straight. Hydrocodone/acetaminophen 325/10 goes for $10? Seems cheap.

Other way around. And that's pricey as **** if you're addicted and taking 30+ a day.

patteeu · 06-05-2016, 09:17 AM

Quote:

Originally Posted by listopencil

That's not true.

Quote:

Originally Posted by JASONSAUTO

For sure. I'm sure I've experienced REAL pain in my life, marijuana definitely helps.

Quote:

Originally Posted by listopencil

I haven't used it myself. But I have very personal first hand experience with people who have, and it helped them quite a bit.

The issue here isn't whether it helps at all, it's whether it's as effective as narcotics. It isn't.

patteeu · 06-05-2016, 09:23 AM

Quote:

Originally Posted by 'Hamas' Jenkins

Opioids absolutely are.

Did you have to panic google this before you decided to agree with me?

Quote:

Originally Posted by 'Hamas' Jenkins

The error is in stating that cannabinoids have no efficacy as analgesics. They do via multiple pathways that I listed.

No, that wasn't the error, because that isn't what anyone said. To the extent that one part of one of my posts seemed to say that when isolated from it's context, I've already provided clarification.

patteeu · 06-05-2016, 09:28 AM

Quote:

Originally Posted by 'Hamas' Jenkins

The fact that you are trying to equate me with someone who is lionizing marijuana shows how desperate and ignorant you are.

Regarding the rest of your braindead tripe, here are the scientific studies you asked for, but won't read and won't apologize for bullshitting about:

Mechanism of ActionDronabinol (synthetic delta-9-tetrahydrocannabinol [delta-9-THC]), an active cannabinoid and natural occurring component of Cannabis sativa L. (marijuana), activates cannabinoid receptors CB1 and CB2. Activation of the CB1 receptor produces marijuana-like effects on psyche and circulation, whereas activation of the CB2 receptor does not. Dronabinol has approximately equal affinity for the CB1 and CB2 receptors; however, efficacy is less at CB2 receptors. Activation of the cannabinoid system with dronabinol causes psychological effects that can be divided into 4 groups: affective (euphoria and easy laughter); sensory (increased perception of external stimuli and of the person’s own body); somatic (feeling of the body floating or sinking in the bed); and cognitive (distortion of time perception, memory lapses, difficulty in concentration). Most effects (eg, analgesia, appetite enhancement, muscle relaxation, hormonal actions) are mediated by central cannabinoid receptors (CB1), their distribution reflecting many of the medicinal benefits and adverse effects (Grotenhermen 2003).

Studies demonstrating their efficacy in treating various types of pain:

Neuropathy:

http://www.ncbi.

.nih.gov/pmc/articles/PMC2755639/

Cannabinoids as an adjunct to Opioids for those with long-term/chronic pain:

http://www.ncbi.

.nih.gov/pmc/articles/PMC3728280/

Cannabinoids' multiple uses in treating cancer (extensive references to pain relief).

http://www.ncbi.

.nih.gov/pmc/articles/PMC4171598/

So, yeah. I'm projecting *my* ignorance. If you'd like, I could also shove a database of Clinical Pharmacology up your bloviating cloaca, you degenerate ****ing ****.

I hope you have more schooling ahead of you before they let you start doling out drugs to real people.

None of those studies are responsive. For example, do you know what the word "adjunct" means? Google it if you don't. Quote the part of those studies where the favorable pain relief comparison to standard narcotics is discussed.

**SAUTO** · 06-05-2016, 10:43 AM

Quote:

Originally Posted by patteeu

The issue here isn't whether it helps at all, it's whether it's as effective as narcotics. It isn't.

i wouldnt know, i stated previously i dont take pain pills.

and im pretty sure i know what pain is...

patteeu · 06-05-2016, 10:53 AM

Quote:

Originally Posted by JASONSAUTO

i wouldnt know, i stated previously i dont take pain pills.

and im pretty sure i know what pain is...

Well, there you go then.

**SAUTO** · 06-05-2016, 11:16 AM

Quote:

Originally Posted by patteeu

Well, there you go then.

I've never said either.

And it wasn't my point.

I went to four doctors with my pops in the past couple months and every one offered him more oxycontins. (In Kansas btw) at every appointment.

Even though he had over a thousand pills at home and multiple refills on several scripts.

We declined the offers...

04-21-2016, 10:57 AM
siberian khatru 21st Century Schizoid Fan Join Date: Jul 2002 Location: The Gates of Delirium Casino cash: $2314950	RIP Prince http://www.tmz.com/2016/04/21/prince-dead-at-57/ Updated link: http://www.news-journalonline.com/ar...nce-dead-at-57 Last edited by siberian khatru; 04-21-2016 at 11:18 AM..
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