I've seen it twice now too. Can totally tell who reads the comics in the theater by their reaction. About half the crowd laughs at Bob or cheers at the Sister Margaret's plaque, etc. Everyone cracked up with baby hand!
The sheer number of digs on the X-Men movies was just insane. I thought it was hilarious, but I was one of the few who laughed at the McAvoy/Steward and continuity jokes. The Yakov joke bombed in both showings I went too, but the tone may have been off in that scene.
While everyone I went with loved it, I felt like many of them really missed out on some great humor by not being comic book fans, just fans of Marvel movies.