Autoplaying videos kind of defeat the purpose of the spoiler shield.
Also, the eyeless guy is a minor character called
Reader. Who knows how closely he'll stick to his comic version; the teleportation would suggest that he will be wildly divergent.
I think Raina is a character invented for the show. They had originally expected her to be a short-lived guest star until the actress did so well, and they signed her on for longer. That would suggest her alter ego was not planned out long in advance (as I'm sure Bobbi was).
And yeah, Skye is Daisy Johnson/Quake. Kyle McLachlan is her father Calvin Zabo/Mr. Hyde, and old Thor villain who, in the comics, is approximately the size of a city bus.