My current favorite Antivirus programs:
BitDefender Free
Avast Free
Malware/Spyware:
Malwarebytes Pro (Pro version is $25, but provides real-time protection instead of a passive scanner. It's great at preventing threats and probably the best at removing existing infections.
I've not had good luck with Security Essentials. I've had to clean up quite a few infections now where MSE didn't catch something it should have.
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