I'm going to be gallant and gracious, and offer Frankie another out in this thread:
Yes, it IS possible that fatigue could lead to a massive failure of the fuselage of a commercial aircraft, although this has never happened in over 80 years of commercial aircraft operations. Therefore, it is highly unlikely in the extreme that such a failure will happen in flight. Therefore, no Frankie, you don't need to worry about it happening. No more so than you do about monkeys flying out of your anus (which is also possible).
I think the young people enjoy it when I "get down," verbally, don't you?